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The endogenous cannabinoid 2-arachidonoyl glycerol: a novel mediator in the brain.
During the last decade, considerable research has been devoted to the identification of an endogenous cannabinoid ligand in brain. However, it was only quite recently that the first putative endogenous ligand for the CNS cannabinoid receptor system, 2-arachidonoyl glycerol (2-AG), was isolated and characterized. These studies have revealed an unprecedented variety of novel neurobiological functions of the endogenous cannabinoid system. 2-AG produces neuroprotective, anti-inflammatory, and pro-apoptotic actions in neuronal and non-neuronal cells. Furthermore, 2-AG is released in the CNS, where it can act as a retrograde messenger at GABAergic synapses. Moreover, it is widely expressed throughout the central nervous system. The results reviewed here provide compelling evidence for the involvement of endogenous 2-AG in modulating physiological and pathological functions of the brain, and suggest that this novel type of neuroactive lipid might be considered a novel neurotransmitter/neuromodulator, acting not only as a retrograde messenger, but also as a local regulator of a number of brain functions.In this vid we have the greater-than-anybody tramp getting up from a tub, deciding to attempt to pummel once more and seeing how it goes. Youth’s laughing, he�

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Chad Allen Wells, 21, was taken into custody at the Walnut Ridge Municipal Court and charged with the unlawful sale of a controlled substance and drug possession.

According to a statement from the drug task force, Wells was arrested with a brick of crack cocaine in his left pant pocket.

Lt. Trent Cearnal, Dothan Police Department’s chief criminal investigator, said Wells allegedly sold a detective $50 worth of crack cocaine and then was searched again at the city’s police department.

The detective allegedly found an additional $50 in Wells’ front pocket, which officers said was the remainder of the drug sale.

Wells’ bond was set at $4,000.

Wells was released from the jail at 4:50 p.m. Friday and was set to appear in court on June 26.

Times Record Reporter

Posted at
Jun. 25, 2013, at 11:39 AM

Dothan: Police make big drug bust

ROBERTS, OK — Investigators said they make big drug busts like this all the time, but the stakes are much higher when the drug is a deadly synthetic drug.

“This is a very, very large drug seizure for the division. We were pretty happy about it. The street-level dealers weren’t happy about it,” said Lt. Trent Cearnal, Dothan Police Department’s chief criminal investigator.

“This isn’t the first time we’ve taken him in for this type of
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